2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W013636BR
    Calcium 2-oxoglutarate (Standard) 71686-01-6
    Calcium 2-oxoglutarate (Standard) is the analytical standard of Calcium 2-oxoglutarate (HY-W013636B). This product is intended for research and analytical applications. Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM).
    Calcium 2-oxoglutarate (Standard)
  • HY-W014839S1
    Cyclamic acid-d4 sodium 1627119-76-9 98%
    Cyclamic acid-d4 (Sodium cyclamate-d4) sodium is the deuterium labeled Cyclamic acid sodium (HY-W014839). Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine.
    Cyclamic acid-d4 sodium
  • HY-W014901S1
    Bisphenol F-13C12 1410794-08-9 98%
    Bisphenol F-13C12 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260).
    Bisphenol F-13C12
  • HY-W015780S1
    1,4-Dimethoxybenzene-d4 21383-12-0 98%
    1,4-Dimethoxybenzene-d4 is the deuterium labeled 1,4-Dimethoxybenzene (HY-W015780).1,4-Dimethoxybenzene is an endogenous metabolite.
    1,4-Dimethoxybenzene-d4
  • HY-W017018S1
    L-Ornithine-1,2-13C2 hydrochloride 224054-19-7 98%
    L-Ornithine-1,2-13C2 (hydrochloride) is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
    L-Ornithine-1,2-13C2 hydrochloride
  • HY-W141978S1
    DL-Lysine-d8 dihydrochloride 284664-87-5 98%
    DL-Lysine-d8 (dihydrochloride) is the deuterium labeled DL-Lysine.
    DL-Lysine-d8 dihydrochloride
  • HY-122666
    Org 25935 949588-40-3 98%
    Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC50 value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse.
    Org 25935
  • HY-127011
    7-Acetylintermedine 74243-01-9 98%
    7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid.
    7-Acetylintermedine
  • HY-17571S
    Oxytocin-13C6,15N TFA
    Oxytocin-13C6,15N (α-Hypophamine-13C6,15N) TFA is the 13C- and 15N-labeled Oxytocin TFA. Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.
    Oxytocin-13C6,15N TFA
  • HY-P0036S
    Octreotide-d8 TFA 98%
    Octreotide-d8 (SMS 201-995-d8) TFA is the deuterium labeled Octreotide TFA. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.
    Octreotide-d8 TFA
  • HY-Y0068S
    N-Acetyl-L-phenylalanine-13C2
    N-Acetyl-L-phenylalanine-13C2 (N-Acetylphenylalanine-13C2) is the 13C-labeled N-Acetyl-L-phenylalanine (HY-Y0068). N-Acetyl-L-phenylalanine (N-Acetylphenylalanine) is a principal acylamino acid. N-Acetyl-L-phenylalanine can be synthesized from L-phenylalanine and acetyl-CoA. N-Acetyl-L-phenylalanine can be used in kidney research.
    N-Acetyl-L-phenylalanine-13C2
  • HY-124208A
    L-770644 dihydrochloride 182251-68-9 98%
    L-770644 is an orally active, potent and selective agonist of the human β3 adrenergic receptor (EC50 = 13 nM).
    L-770644 dihydrochloride
  • HY-B0627S1
    Metformin-13C2 hydrochloride 98%
    Metformin-13C2 (1,1-Dimethylbiguanide-13C2) hydrochloride is the 13C-labeled Metformin hydrochloride (HY-17471A). Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.
    Metformin-13C2 hydrochloride
  • HY-G0008AR
    O-Desmethyl Mebeverine alcohol hydrochloride (Standard) 856620-39-8
    Diethyl phthalate (Standard) is the analytical standard of Diethyl phthalate. This product is intended for research and analytical applications. Diethyl phthalate is an endocrine disruptor that has the activity of affecting the apoptosis system of PC12 cells. Diethyl phthalate is widely used in a variety of plastics and personal care products. Diethyl phthalate has shown the potential to induce male reproductive toxicity unrelated to androgens in animal experiments.
    O-Desmethyl Mebeverine alcohol hydrochloride (Standard)
  • HY-N0176S6
    Dihydroartemisinin-d 252043-36-0 98%
    Dihydroartemisinin-d (Dihydroqinghaosu-d) is the deuterium labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.
    Dihydroartemisinin-d
  • HY-W753763
    Sucrose-13C12 1217464-95-3 98%
    Sucrose-13C12 (D-(+)-Saccharose-13C12) is the 13C-labeled Sucrose (HY-B1779). Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al.
    Sucrose-13C12
  • HY-135035S1
    Decanoyl-L-carnitine-d19 98%
    Decanoyl-L-carnitine-d19 ((-)-Decanoylcarnitine-d19> is the deuterium labeled Decanoyl-L-carnitine (HY-135035). Decanoyl-L-carnitine ((-)-Decanoylcarnitine) is an endogenous metabolite. Decanoyl-L-carnitine can be used as a serum metabolic biomarkers as indicators in the progression of intravenous leiomyomatosis.
    Decanoyl-L-carnitine-d19
  • HY-15267A
    (24R)-MC 976 112828-09-8 98%
    (24R)-MC 976 is a Vitamin D3 derivative.
    (24R)-MC 976
  • HY-15267B
    (24S)-MC 976 112849-14-6
    (24S)-MC 976 is a Vitamin D3 derivative.
    (24S)-MC 976
  • HY-P0245
    Speract 76901-59-2 98%
    Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.
    Speract
Cat. No. Product Name / Synonyms Application Reactivity